Toxicity caused by Chelidonium majus in primary human, canine, monkey, and rat hepatocytes
نویسندگان
چکیده
منابع مشابه
Chelidonium majus-Induced Acute Hepatitis
Medicinal herbs, defined as preparations concocted by an unauthorized layperson [1], are used widely in Asian countries because they are easily available and are believed to be harmless. Despite this belief, hepatitis, and even fulminant hepatitis, associated with medicinal herbs has been reported. According to previous reports, drug-induced liver injury accounts for 2~40% of all liver injury [...
متن کاملChelidonium majus 30C and 200C in induced hepato-toxicity in rats.
INTRODUCTION Homeopathy is a popular form of complementary and alternative medicine and is used to treat for certain liver ailments. AIM To analyze the efficacy of homeopathic Chelidonium majus (Chel) 30C and 200C in amelioration of experimentally induced hepato-toxicity in rats. METHODS Rats were randomized into six sub-groups: negative control; negative control+EtOH; positive control; pos...
متن کاملInhibition of mouse liver respiration by Chelidonium majus isoquinoline alkaloids.
The alkaloids from Chelidonium majus L. which had a significant inhibitory effect in mitochondrial respiration were those which contain a positive charge due to a quaternary nitrogen atom, i.e., chelerythrine, sanguinarine, berberine and coptisine, both with malate+glutamate or with succinate as substrates. When malate+glutamate was used as substrate, chelerythrine and berberine, which contain ...
متن کاملChelidonium majus--an integrative review: traditional knowledge versus modern findings.
Chelidonium majus L. (family Papaveraceae), or greater celandine, is an important plant in western phytotherapy and in traditional Chinese medicine. Crude extracts of C. majus as well as purified compounds derived from it exhibit a broad spectrum of biological activities (antiinflammatory, antimicrobial, antitumoral, analgesic, hepatoprotective) that support some of the traditional uses of C. m...
متن کاملP-4: Grape Seed Extract Alleviate Male Reproductive Toxicity Caused by Busulfan in Rat Model
Background: The alkylating agent busulfan adversely affects spermatogenesis in mammals and Impairment of spermatogenesis has been identified as an inevitable side effect of cancer treatment druges then the aim of this study was to investigate the possible protective effects of Grape seed extract with potent antioxidant activity, on busulfan-treated adult male mice. Materials and Methods: In thi...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.741.15